MS06-02 - Structural Basis of Ribosomal RNA Synthesis in Bacteria


Yong-Heng Huang (FU Berlin, Germany)

Ribosomal RNA synthesis in Escherichia coli involves a transcription elongation complex (EC), in which RNA polymerase is modified by a signal element on the transcript, Nus factors A, B, E and G, ribosomal protein S4 and inositol mono-phosphatase SuhB. This EC is resistant to ρ-dependent termination and facilitates ribosomal RNA folding, maturation and subunit assembly. I will report on recent results from our lab on the functional architecture of the ribosomal RNA EC.